Volume 17 , Issue 2 , PP: 409-426, 2025 | Cite this article as | XML | Html | PDF | Full Length Article
Arwa Darwish Alzughaibi 1 *
Doi: https://doi.org/10.54216/FPA.170230
Leukemia is a form of blood cancer that targets white blood cells (WBC) and stands as a major cause of mortality worldwide. During the center of human bones, leukaemia is presented and provides blood cell generation with leukocytes and WBC, and if some cell comes to be blasted, then it grows a fatal illness. For that reason, the analysis of leukaemia in its initial stages aids significantly in the treatment accompanied by saving the life. At present, leukemia analysis is done by visual assessment of biomedical images of blood cells, which is time-consuming, tedious, and wants to train specialists. Consequently, the lack of an early, automatic, and effectual leukemia recognition model is a major problem in hospitals. A few automated techniques like deep learning (DL) and Machine learning (ML) methodologies for leukemia cancer identification are presented that offer remarkable and effectual results. This study develops a Robust Multimodal Fusion of Transfer Learning Framework for Leukemia Cancer Detection and Classification (RMFTLF-LCDC) algorithm. The RMFTLF-LCDC system mostly suggests identifying and classifying the existence of leukemia cancer on biomedical imaging. At first, the RMFTLF-LCDC model applies image preprocessing using a kernel correlation filter (KCF) to eliminate the noise. For the feature extraction process, the multimodal fusion of CapsNet models, including RES-CapsNet, VGG-CapsNet, and GN-CapsNet are implemented to improve the representation of features by providing more accurate initial information to subsequent capsule layers. In addition, the recurrent spiking neural network with the spiking convolutional block attention module (RSNN-CBAM) technique is performed for the leukemia cancer detection process. At last, the improved Harris hawk optimization (IHHO) approach-based hyperparameter choice can be executed to improve the classification outcomes of the RSNN-CBAM system. The efficiency of the RMFTLF-LCDC method has been validated by comprehensive studies using the benchmark image dataset. The numerical result shows that the RMFTLF-LCDC method has better performance and scalability across other recent techniques.
Leukemia Cancer Detection , Multimodal Fusion , Improved Harris Hawk Optimization , Biomedical Images , CapsNet
[1] Saeed, U., Kumar, K., Khuhro, M.A., Laghari, A.A., Shaikh, A.A. and Rai, A., DeepLeukNet—A CNN based microscopy adaptation model for acute lymphoblastic leukemia classification. Multimedia Tools and Applications, 83(7), pp.21019-21043, 2024.
[2] Elsayed, B., Elhadary, M., Elshoeibi, R.M., Elshoeibi, A.M., Badr, A., Metwally, O., ElSherif, R.A., Salem, M.E., Khadadah, F., Alshurafa, A. and Mudawi, D., Deep learning enhances acute lymphoblastic leukemia diagnosis and classification using bone marrow images. Frontiers in Oncology, 13, p.1330977, 2023.
[3] Baig, R., Rehman, A., Almuhaimeed, A., Alzahrani, A. and Rauf, H.T., Detecting malignant leukemia cells using microscopic blood smear images: a deep learning approach. Applied Sciences, 12(13), p.6317, 2022.
[4] Perveen, S., Alourani, A., Shahbaz, M., Ashraf, U. and Hamid, I., A framework for Early Detection of Acute Lymphoblastic Leukemia and its Subtypes from Peripheral Blood Smear Images Using Deep Ensemble Learning Technique. IEEE Access, 2024.
[5] Yadav, D.P., Kumar, D., Jalal, A.S., Kumar, A., Singh, K.U. and Shah, M.A., Morphological diagnosis of hematologic malignancy using feature fusion-based deep convolutional neural network. Scientific Reports, 13(1), p.16988, 2023.
[6] Sampathila, N., Chadaga, K., Goswami, N., Chadaga, R.P., Pandya, M., Prabhu, S., Bairy, M.G., Katta, S.S., Bhat, D. and Upadya, S.P., 2022, September. Customized deep learning classifier for detection of acute lymphoblastic leukemia using blood smear images. In Healthcare (Vol. 10, No. 10, p. 1812). MDPI.
[7] Islam, M.M., Rifat, H.R., Shahid, M.S.B., Akhter, A. and Uddin, M.A., Utilizing Deep Feature Fusion for Automatic Leukemia Classification: An Internet of Medical Things-Enabled Deep Learning Framework. Sensors (Basel, Switzerland), 24(13), 2024.
[8] Gondal, C.H.A., Irfan, M., Shafique, S., Bashir, M.S., Ahmed, M., Alshehri, O.M., Almasoudi, H.H., Alqhtani, S.M., Jalal, M.M., Altayar, M.A. and Alsharif, K.F., Automated Leukemia Screening and Sub-types Classification Using Deep Learning. Computer Systems Science & Engineering, 46(3), 2023.
[9] Sinha, R., Sinha, K.K., Patel, M., Gupta, S. and Priya, S., Detection of Leukemia Disease using Convolutional Neural Network. In 2024 5th International Conference on Image Processing and Capsule Networks (ICIPCN) (pp. 451-456). IEEE, 2024.
[10] Menagadevi, M., Nirmala, M., Thiyagarajan, D. and Rajkumar, R., Web-based Approach for Detection of Acute Lymphoblastic Leukemia From Microscopic Blood Cell Images Using Convolutional Neural Network, 2023.
[11] Asar, T.O. and Ragab, M., Leukemia detection and classification using computer-aided diagnosis system with falcon optimization algorithm and deep learning. Scientific Reports, 14(1), p.21755, 2024.
[12] Ansari, S., Navin, A.H., Sangar, A.B., Gharamaleki, J.V. and Danishvar, S., A customized efficient deep learning model for the diagnosis of acute leukemia cells based on lymphocyte and monocyte images. Electronics, 12(2), p.322, 2023.
[13] Alim, M.S., Bappon, S.D., Sabuj, S.M., Islam, M.J., Tarek, M.M., Azam, M.S. and Islam, M.M., Integrating convolutional neural networks for microscopic image analysis in acute lymphoblastic leukemia classification: A deep learning approach for enhanced diagnostic precision. Systems and Soft Computing, 6, p.200121, 2024.
[14] Elhassan, T.A., Mohd Rahim, M.S., Siti Zaiton, M.H., Swee, T.T., Alhaj, T.A., Ali, A. and Aljurf, M., Classification of atypical white blood cells in acute myeloid leukemia using a two-stage hybrid model based on deep convolutional autoencoder and deep convolutional neural network. Diagnostics, 13(2), p.196, 2023.
[15] Jawahar, M., Anbarasi, L.J., Narayanan, S. and Gandomi, A.H., An attention-based deep learning for acute lymphoblastic leukemia classification. Scientific Reports, 14(1), p.17447, 2024.
[16] Vinurajan, I., Optimal Attention based Deep Learning with Segmentation Approach for Automated Leukemia Detection and Classification. Power System Technology, 47(2), 2023.
[17] Yenurkar, G.K., Mal, S., Thakur, N., Dhomne, S., Dhurve, M., Patel, M., Kulmeti, K. and Dhurve, H., DeepLeuk: a convolutional neural network pre-trained model for microscopic cell images-Based leukemia Cancer analysis. Multimedia Tools and Applications, pp.1-34, 2024.
[18] Batool, A. and Byun, Y.C., 2023. Lightweight EfficientNetB3 model based on depthwise separable convolutions for enhancing classification of leukemia white blood cell images. IEEE access, 11, pp.37203-37215, 2023.
[19] Yue, W., Xu, F. and Yang, J., Tracking-by-Detection Algorithm for Underwater Target Based on Improved Multi-Kernel Correlation Filter. Remote Sensing, 16(2), p.323, 2024.
[20]
Aydin Atasoy, N. and Faris Abdulla Al Rahhawi, A., Examining the classification performance of preātrained capsule networks on imbalanced bone marrow cell dataset. International Journal of Imaging Systems and Technology, 34(3), p.e23067, 2024.
[21] Xu, Q., Gao, Y., Shen, J., Li, Y., Ran, X., Tang, H. and Pan, G., Enhancing adaptive history reserving by spiking convolutional block attention module in recurrent neural networks. Advances in Neural Information Processing Systems, 36, 2024.
[22] Tang, C., Li, W., Han, T., Yu, L. and Cui, T., Multi-Strategy Improved Harris Hawk Optimization Algorithm and Its Application in Path Planning. Biomimetics, 9(9), p.552, 2024.
[23] https://www.kaggle.com/datasets/andrewmvd/leukemia-classification
[24] Saeed, A., Shoukat, S., Shehzad, K., Ahmad, I., Eshmawi, A.A., Amin, A.H. and Tag-Eldin, E., A deep learning-based approach for the diagnosis of acute lymphoblastic leukemia. Electronics, 11(19), p.3168, 2022.
[25] More, P. and Sugandhi, R., Automated and enhanced leucocyte detection and classification for leukemia detection using multi-class SVM classifier. Engineering Proceedings, 37(1), p.36, 2023.
[26] Sulaiman, A., Kaur, S., Gupta, S., Alshahrani, H., Reshan, M.S.A., Alyami, S. and Shaikh, A., ResRandSVM: Hybrid approach for acute lymphocytic leukemia classification in blood smear images. Diagnostics, 13(12), p.2121, 2023.
[27] Smarandache, F., Neutrosophic set a generalization of the intuitionistic fuzzy sets. Inter. J. Pure Appl. Math., 24, 287 – 297, 2005.
[28] Salama, A. A., Smarandache, F., & Kroumov, V., Neutrosophic crisp Sets & Neutrosophic crisp Topological Spaces. Sets and Systems, 2(1), 25-30, 2014.
[29] Smarandache, F. & Pramanik, S. (Eds). (2016). New trends in neutrosophic theory and applications. Brussels: Pons Editions.
[30] Alhabib, R., The Neutrosophic Time Series, the Study of Its Linear Model, and test Significance of Its Coefficients. Albaath University Journal, Vol.42, 2020, (Arabic version).