Volume 11 , Issue 2 , PP: 90-110, 2023 | Cite this article as | XML | Html | PDF | Full Length Article
S. Hemamalini 1 * , V. D. Ambeth Kumar 2 , R. Venkatesan 3 , S. Malathi 4
Doi: https://doi.org/10.54216/FPA.110207
In computer vision, multi-label classification (MLC) is especially important for medical picture analysis. We use MLC to classify diverse stages of diabetic retinopathy (DR) using colour fundus pictures of varying brightness and contrast. As a result, ophthalmologists can now identify the early warning symptoms of DR and the varying stages of DR, allowing them to begin therapy sooner and prevent further difficulties. Using the outlier-based shallow regularization fuzzy clustering approach (OSR-FCA), for classification we present a deep learning method in this paper's picture segmentation task. The fundamental feature of the proposed system is the ability to identify and analyse different degenerative changes in the retina that occur alongside the progression of DR without requiring the patient to undergo costly diagnostic procedures like dye injections. Photographs are first resized, converted to grayscale, cleaned of noise, and the contrast increased by the use of histogram equalization adopting the CLAHE method. The clipping limit of CLAHE is optimized by the help of the rat optimization algorithm, which is applied throughout the histogram process. In addition, a Gaussian metric regularization to the objective function in OSR-FCA is a great way to enhance clustering approaches that use fuzzy membership with sparseness which is based on neutrosophic set. This research proposes a new approach called "Relevance Mapping on Multi-Class Label" (RMMCL) for locating and viewing regions of interest (ROI) inside a segmented picture. These representations give better explanations for the predictions of the DL model founded on a convolutional neural network-(CNN). The validation of two ML datasets showed the projected model outperformed the existing models by achieving an average correctness of 97.27 percent over five stages of the IDRID dataset.
Multi-label classification , Relevance Mapping , Outlier-based skimpy regularization fuzzy clustering technique , Regions of interest , Convolutional neural network.
[1] Wan, C., Chen, Y., Li, H., Zheng, B., Chen, N., Yang, W., Wang, C. and Li, Y., 2021. EAD-net: a novel lesion segmentation method in diabetic retinopathy using neural networks. Disease Markers, 2021.
[2] Xu, Y., Zhou, Z., Li, X., Zhang, N., Zhang, M. and Wei, P., 2021. Ffu-net: Feature fusion u-net for lesion segmentation of diabetic retinopathy. BioMed Research International, 2021.
[3] Garifullin, A., Lensu, L. and Uusitalo, H., 2021. Deep Bayesian baseline for segmenting diabetic retinopathy lesions: Advances and challenges. Computers in Biology and Medicine, 136, p.104725.
[4] Abdelmaksoud, E., El-Sappagh, S., Barakat, S., Abuhmed, T. and Elmogy, M., 2021. Automatic diabetic retinopathy grading system based on detecting multiple retinal lesions. IEEE Access, 9, pp.15939-15960.
[5] Dai, L., Wu, L., Li, H., Cai, C., Wu, Q., Kong, H., Liu, R., Wang, X., Hou, X., Liu, Y. and Long, X., 2021. A deep learning system for detecting diabetic retinopathy across the disease spectrum. Nature communications, 12(1), p.3242.
[6] Zhou, Y., Wang, B., Huang, L., Cui, S. and Shao, L., 2020. A benchmark for studying diabetic retinopathy: segmentation, grading, and transferability. IEEE Transactions on Medical Imaging, 40(3), pp.818-828.
[7] Van Craenendonck, T., Elen, B., Gerrits, N. and De Boever, P., 2020. Systematic comparison of heatmapping techniques in deep learning in the context of diabetic retinopathy lesion detection. Translational vision science & technology, 9(2), pp.64-64.
[8] Sambyal, N., Saini, P., Syal, R. and Gupta, V., 2020. Modified U-Net architecture for semantic segmentation of diabetic retinopathy images. Biocybernetics and Biomedical Engineering, 40(3), pp.1094-1109.
[9] Erciyas, A. and Barışçı, N., 2021. An effective method for detecting and classifying diabetic retinopathy lesions based on deep learning. Computational and Mathematical Methods in Medicine, 2021, pp.1-13.
[10] Porwal, P., Pachade, S., Kokare, M., Deshmukh, G., Son, J., Bae, W., Liu, L., Wang, J., Liu, X., Gao, L. and Wu, T., 2020. Idrid: Diabetic retinopathy–segmentation and grading challenge. Medical image analysis, 59, p.101561.
[11] Lakshminarayanan, V., Kheradfallah, H., Sarkar, A. and Jothi Balaji, J., 2021. Automated detection and diagnosis of diabetic retinopathy: A comprehensive survey. Journal of Imaging, 7(9), p.165.
[12] Colomer, A., Igual, J. and Naranjo, V., 2020. Detection of early signs of diabetic retinopathy based on textural and morphological information in fundus images. Sensors, 20(4), p.1005.
[13] Qiao, L., Zhu, Y. and Zhou, H., 2020. Diabetic retinopathy detection using prognosis of microaneurysm and early diagnosis system for non-proliferative diabetic retinopathy based on deep learning algorithms. IEEE Access, 8, pp.104292-104302.
[14] Mateen, M., Wen, J., Nasrullah, N., Sun, S. and Hayat, S., 2020. Exudate detection for diabetic retinopathy using pretrained convolutional neural networks. Complexity, 2020, pp.1-11.
[15] Zago, G.T., Andreão, R.V., Dorizzi, B. and Salles, E.O.T., 2020. Diabetic retinopathy detection using red lesion localization and convolutional neural networks. Computers in biology and medicine, 116, p.103537.
[16] Huang, S., Li, J., Xiao, Y., Shen, N. and Xu, T., 2022. RTNet: relation transformer network for diabetic retinopathy multi-lesion segmentation. IEEE Transactions on Medical Imaging, 41(6), pp.1596-1607.
[17] Guo, Y. and Peng, Y., 2022. CARNet: Cascade attentive RefineNet for multi-lesion segmentation of diabetic retinopathy images. Complex & Intelligent Systems, 8(2), pp.1681-1701.
[18] Wang, X., Fang, Y., Yang, S., Zhu, D., Wang, M., Zhang, J., Zhang, J., Cheng, J., Tong, K.Y. and Han, X., 2023. CLC-Net: Contextual and Local Collaborative Network for Lesion Segmentation in Diabetic Retinopathy Images. Neurocomputing.
[19] Upadhyay, K., Agrawal, M. and Vashist, P., 2023. Characteristic patch-based deep and handcrafted feature learning for red lesion segmentation in fundus images. Biomedical Signal Processing and Control, 79, p.104123.
[20] Aziz, T., Charoenlarpnopparut, C. and Mahapakulchai, S., 2023. Deep learning-based hemorrhage detection for diabetic retinopathy screening. Scientific Reports, 13(1), p.1479.
[21] Nahiduzzaman, M., Islam, M.R., Goni, M.O.F., Anower, M.S., Ahsan, M., Haider, J. and Kowalski, M., 2023. Diabetic Retinopathy Identification Using Parallel Convolutional Neural Network Based Feature Extractor and ELM Classifier. Expert Systems with Applications, p.119557.
[22] Gu, Z., Li, Y., Wang, Z., Kan, J., Shu, J. and Wang, Q., 2023. Classification of Diabetic Retinopathy Severity in Fundus Images Using the Vision Transformer and Residual Attention. Computational Intelligence and Neuroscience, 2023.
[23] Dhiman, G., Garg, M., Nagar, A., Kumar, V. and Dehghani, M., 2021. A novel algorithm for global optimization: rat swarm optimizer. Journal of Ambient Intelligence and Humanized Computing, 12(8), pp.8457-8482.
[24]. Bhardwaj C, Jain S, Sood M: Automated Optical disc segmentation and blood vessel extraction for fundus images using ophthalmic image processing. In International Conference on Advanced Informatics for Computing Research. Springer, Singapore, pp. 182–194, 2018.
[25]. Niemeijer M, Staal J, Ginneken BV, Loog M, Abramoff MD: Comparative study of retinal vessel segmentation methods on a new publicly available database. In Medical Imaging 2004: Image Processing. International Society for Optics and Photonics. 5370, pp. 648–657, 2004.
[26]. Rahim SS, Palade V, Shuttleworth J, Jayne C: Automatic screening and classification of diabetic retinopathy and maculopathy using fuzzy image processing. Brain Inf. 3(4), 249–267, 2016
[27] Y. Zhang, X. Bai, R. Fan, and Z. Wang, ‘‘Deviation-sparse fuzzy C-means with neighbor information constraint,’’ IEEE Trans. Fuzzy Syst., vol. 27, no. 1, pp. 185–199, Jan. 2019
[28] L. Guo, L. Chen, X. Lu, and C. L. P. Chen, ‘‘Membership affinity lasso for fuzzy clustering,’’ IEEE Trans. Fuzzy Syst., vol. 28, no. 2, pp. 294–307, Feb. 2020
[29] S. Miyamoto and M. Mukaidono, ‘‘Fuzzy C-means as a regularization and maximum entropy approach,’’ in Proc. 7th Int. Fuzzy Syst. Assoc. World Congr., Prague, Czech Republic, 1997, pp. 86–92.
[30] J. Huang, F. Nie, and H. Huang, ‘‘A new simplex sparse learning model to measure data similarity for clustering,’’ in Proc. 24th Int. Joint Conf. Artif. Intell., Buenos Aires, Argentina, 2015, pp. 3569–3575.
[31] Santoso, K.A., Kurniawan, M.B., Kamsyakawuni, A. and Riski, A., 2022, February. Hybrid Cat-Particle Swarm Optimization Algorithm on Bounded Knapsack Problem with Multiple Constraints. In International Conference on Mathematics, Geometry, Statistics, and Computation (IC-MaGeStiC 2021) (pp. 244-248). Atlantis Press.
[32] Zhou, B.; Khosla, A.; Lapedriza, A.; Oliva, A.; Torralba, A. Learning deep features for discriminative localization. In Proceedings of the IEEE Conference on Computer Vision Pattern Recognition (CVPR), Las Vegas, NV, USA, 26 June–1 July 2016; pp. 2921–2929.
[33] Selvaraju, R.R.; Cogswell, M.; Das, A.; Vedantam, R.; Parikh, D.; Batra, D. Grad-CAM: Visual explanations from deep networks via gradient-based localization. In Proceedings of the International conference, Computer Vision Pattern Recognition (CVPR), Honolulu, HI, USA, 21–26 July 2017; pp. 618–626.
[34] Messidor Dataset, [online]. Available: http://www.adcis.net/en/third-party/messidor/
[35] Furtado, P., Baptista, C. and Paiva, I., 2020, February. Segmentation of Diabetic Retinopathy Lesions by Deep Learning: Achievements and Limitations. In Bioimaging (pp. 95-101).