International Journal of Neutrosophic Science IJNS 2690-6805 2692-6148 10.54216/IJNS https://www.americaspg.com/journals/show/4184 2020 2020 Universidad Regional Autónoma de los Andes (UNIANDES), Campus Ibarra, Ecuador Verà Verónica Universidad Regional Autónoma de los Andes (UNIANDES), Campus Ibarra, Ecuador Danna Carolina Oliveros Acosta Universidad Regional Autónoma de los Andes (UNIANDES), Campus Ibarra, Ecuador Patricia Alexandra Guajan Leà León The purpose of the study was to implement a patient classification for cleft lip and palate (CLP) patients according to their overall etiopathogenic risk profile given the multifactorial yet uncertain etiology of the disorder. To do this, a novel approach was made based on Plitogenic Fuzzy Soft Set Theory, which accommodates the simultaneous inexactness of clinically and epidemiologically derived information, ambiguous relationships of risk factors and indeterminacy of absent or conflicting information. A series of etiopathogenic parameters (genetic, environmental, and behavioral) were proposed as attributes and a set of plitogenic membership functions was used to assess each patient. Major findings enabled the classification of patients into certain risk levels (e.g. , high genetic risk, environmental dominance with less caution, mixed risk but dominantly high indeterminacy) and reveal factor composition patterns that would otherwise be invisible to classical statistical analyses. It was concluded that this model provides a superior clinical decision support system that is personalized since it quantifies the uncertainty of FLAP's etiology for more accurate risk stratification and preventative or early intervention planning more applicable to the complicated reality of all patients. 2025 2025 388 399 10.54216/IJNS.260329 https://www.americaspg.com/articleinfo/21/show/4184