Journal of Intelligent Systems and Internet of Things JISIoT 2690-6791 2769-786X 10.54216/JISIoT https://www.americaspg.com/journals/show/3723 2019 2019 Computer Science Department, University of Anbar, Ramadi, Iraq; Department of Basic Science, College of Dentistry, University of Baghdad, Iraq Woud Woud Computer Science Department, University of Anbar, Ramadi, Iraq Murtadha M. Hamad Computer Science Department, University of Anbar, Ramadi, Iraq Azmi Tawfeq Hussein Alrawi This study investigates combining fuzzy logic with deep learning methodologies in classifying X-ray images for osteoporosis detection. Osteoporosis, defined by compromised bone integrity and heightened fracture susceptibility, requires prompt and precise diagnosis for effective treatment. We devised a hybrid approach that amalgamates transfer learning from Convolutional Neural Network (CNN) architectures, including MobileNetV2, AlexNet, ResNet50V2, and Xception, utilizing fuzzy logic during the preprocessing phase to address uncertainty and imprecision in X-ray images, thereby enhancing the quality of the input data for the subsequent pre-trained models. The research entailed the examination of a significant dataset of X-ray images and the implementation of the proposed methodology to categorize images as osteoporotic or non-osteoporotic, attaining a remarkable accuracy of 99.68% and a receiver operating characteristic (ROC) of 100% through the integration of fuzzy logic preprocessing with ResNet50V2. This innovative method may substantially decrease diagnostic inaccuracies and enhance patient outcomes, facilitating additional research and development in applying deep learning techniques in healthcare. 2025 2025 214 235 10.54216/JISIoT.160216 https://www.americaspg.com/articleinfo/18/show/3723