Fusion: Practice and Applications FPA 2692-4048 2770-0070 10.54216/FPA https://www.americaspg.com/journals/show/3295 2018 2018 Biomedical Computing and Engineering Technologies (BIOCORE) Applied Research Group, Department of Software Engineering, Faculty of Information and Communication Technology, Universiti Teknikal Malaysia Melaka (UTeM), Malaysia Ali Ali Biomedical Computing and Engineering Technologies (BIOCORE) Applied Research Group, Department of Software Engineering, Faculty of Information and Communication Technology, Universiti Teknikal Malaysia Melaka (UTeM), Malaysia Mohd Khanapi Abd Ghani This review provides an in-depth exploration of machine learning (ML) applications in healthcare, focusing specifically on predictive models for COVID-19 transmission among vaccinated individuals. It underscores the pivotal role of ML in disease forecasting and prognosis, showcasing its potential to enhance healthcare outcomes in pandemic contexts. Key challenges of COVID-19, such as the high transmission rate of asymptomatic carriers and the effectiveness of containment strategies, are analyzed to highlight areas where ML can offer significant advantages. The study aims to develop an advanced forecasting model for COVID-19 transmission using diverse supervised ML regression techniques, including linear regression, LASSO, support vector machine, and exponential smoothing, applied to an extensive COVID-19 patient dataset. The insights generated from this review support efforts to combat COVID-19 and improve public health strategies, demonstrating ML's vital contribution to pandemic management and healthcare resilience. 2025 2025 264 278 10.54216/FPA.170220 https://www.americaspg.com/articleinfo/3/show/3295