Volume 10 , Issue 2 , PP: 52–66, 2025 | Cite this article as | XML | Html | PDF | Full Length Article
Doaa Sami Khafaga 1 *
Doi: https://doi.org/10.54216/JAIM.100204
The classification of brain tumors is crucial in the context of early intervention, as the appropriate and timely diagnosis can significantly influence the treatment plan and patient outcomes. Radiologists have long relied on their own judgment and have read these medical images through their own eyes, which is often subjective, time-consuming, and inter-observer variability is also likely to occur. Applications built on artificial intelligence (AI), or more specifically, deep learning (DL)-based algorithms, have radically changed the medical imaging field over the last couple of years and could potentially be used to automate the diagnosis process, offering prompt, trustworthy, and unbiased assessments. Despite such developments, most existing systems that rely on AI are constrained, especially when it comes to classification accuracy and robustness across different datasets. To overcome these problems, the article in this chapter presents a more effective DL model with a specifically designed architecture that aims to improve the classification of brain tumors. The specified methodology is based on preprocessing and data normalization steps that reduce noise and level out the data intensity, enabling effective feature extraction from the MRI images. This will increase the accuracy of the later classification. The primary component of the proposed methodology is an adapted version of DenseNet-201, designed explicitly for the four class brain tumor classification. To achieve optimal performance, the conventional output layer of DenseNet-201 was replaced with a Global Average Pooling (GAP) layer, designed to address the issues of vanishing gradients and overfitting commonly encountered during the training of deep networks. The architectural adjustment helps to combine the features and increase the overall generalization capacity of the model. The model was thoroughly tested using two datasets: one publicly available dataset on Figshare and a locally available dataset comprising a total of 3,504 T1-weighted contrast-enhanced MRI (T1-w MRI) images. The results of the experiment provided the proposed model with a general accuracy of 100 percent, which was higher than that of the existing comparative methods. Such results support the idea that complex architectural adjustments with the broader preprocessing strategy can be effective, and why deep neural networks can be viewed as trustworthy diagnostic tools in clinical neuro-oncology, potentially achieving extremely high accuracy.
Brain tumor , Deep Learning , DenseNet201 , Multi Classification , Transfer Learning
[1] Y.-K. Kim and J. Song, “Metabolic imbalance and brain tumors: The interlinking metabolic pathways and therapeutic actions of antidiabetic drugs,” Pharmacological Research, vol. 215, p. 107 719, 2025, ISSN: 1043-6618. DOI: https : / / doi . org / 10 . 1016 / j . phrs . 2025 . 107719. [Online]. Available: https : / / www . sciencedirect . com / science / article / pii / S1043661825001446.
[2] A. Behin, K. Hoang-Xuan, A. F. Carpentier, and J.-Y. Delattre, “Primary brain tumours in adults,” The Lancet, vol. 361, no. 9354, pp. 323–331, 2003.
[3] A. Hekmat, Z. Zhang, S. Ur Rehman Khan, I. Shad, and O. Bilal, “An attention-fused architecture for brain tumor diagnosis,” Biomedical Signal Processing and Control, vol. 101, p. 107 221, 2025, ISSN: 1746-8094. DOI: https://doi.org/10.1016/j.bspc.2024.107221. [Online]. Available: https://www.sciencedirect.com/science/article/pii/S1746809424012795.
[4] Q. T. Ostrom, N. Patil, G. Cioffi, K. Waite, C. Kruchko, and J. S. Barnholtz-Sloan, “Cbtrus statistical report: Primary brain and other central nervous system tumors diagnosed in the united states in 2013–2017,” Neuro oncology, vol. 22, no. Supplement_1, pp. iv1–iv96, 2020.
[5] K. R. Porter, B. J. McCarthy, S. Freels, Y. Kim, and F. G. Davis, “Prevalence estimates for primary brain tumors in the united states by age, gender, behavior, and histology,” Neuro-oncology, vol. 12, no. 6, pp. 520–527, 2010.
[6] H. Yadav, S. Singh, K. K. Mishra, S. Srivastava, M. S. Naruka, and S. P. Yadav, “Brain tumor detection with mri images,” in 2022 International Conference on Computational Intelligence and Sustainable Engineering Solutions (CISES), 2022, pp. 519–527. DOI: 10.1109/CISES54857 . 2022.9844387.
[7] V. Yamuna, P. RVS, R. Sathya, M. Dhivva, R. Lidiya, and P. Sowmiya, “Integrating ai for improved brain tumor detection and classification,” in 2024 4th International Conference on Sustainable Expert Systems (ICSES), 2024, pp. 1603–1609. DOI: 10.1109/ICSES63445.2024.10763262.
[8] M. Agarwal, G. Rani, A. Kumar, P. Kumar, R Manikandan, and A. H. Gandomi, “Deep learning for enhanced brain tumor detection and classification,” Results in Engineering, vol. 22, p. 102 117, 2024. DOI: https://doi.org/10.1016/j.rineng.2024.102117.
[9] A. Batool and Y.-C. Byun, “Brain tumor detection with integrating traditional and computational intelligence approaches across diverse imaging modalities - challenges and future directions,” Computers in Biology and Medicine, vol. 175, p. 108 412, 2024, ISSN: 0010-4825. DOI: https : //doi.org/10.1016/j.compbiomed.2024.108412. [Online]. Available: https:// www.sciencedirect.com/science/article/pii/S0010482524004967.
[10] S. Khalighi, K. Reddy, A. Midya, K. B. Pandav, A. Madabhushi, and M. Abedalthagafi, “Artificial intelligence in neuro-oncology: Advances and challenges in brain tumor diagnosis, prognosis, and precision treatment,” NPJ precision oncology, vol. 8, no. 1, p. 80, 2024. DOI: https://doi.org/ 10.1038/s41698-024-00575-0.
[11] J. Cheng, Brain tumor dataset. figshare. dataset (2017), 2017.
[12] V. Rathi and S. Palani, “Brain tumor detection and classification using deep learning classifier on mri images,” Research Journal of Applied Sciences, Engineering and Technology, vol. 10, pp. 177–187, May 2015.
[13] A. Kumar, M. A. Ansari, and A. Ashok, “A hybrid framework for brain tumor classification using grey wolf optimization and multi-class support vector machine 7747.”
[14] J. Cheng et al., “Enhanced performance of brain tumor classification via tumor region augmentation and partition,” PloS one, vol. 10, no. 10, e0140381, 2015.
[15] M. R. Ismael and I. Abdel-Qader, “Brain tumor classification via statistical features and back-propagation neural network,” in 2018 IEEE international conference on electro/information technology (EIT), IEEE, 2018, pp. 0252–0257.
[16] T. A. Abir, J. A. Siraji, E. Ahmed, and B. Khulna, “Analysis of a novel mri based brain tumour classification using probabilistic neural network (pnn),” Int. J. Sci. Res. Sci. Eng. Technol, vol. 4, no. 8, pp. 65–79, 2018.
[17] P. Afshar, K. N. Plataniotis, and A. Mohammadi, “Capsule networks for brain tumor classification based on mri images and coarse tumor boundaries,” in ICASSP 2019-2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), IEEE, 2019, pp. 1368–1372.
[18] N. Abiwinanda, M. Hanif, S. T. Hesaputra, A. Handayani, and T. R. Mengko, “Brain tumor classification using convolutional neural network,” in World congress on medical physics and biomedical engineering 2018, Springer, 2019, pp. 183–189.
[19] S Deepak and P. Ameer, “Brain tumor classification using deep cnn features via transfer learning,” Computers in biology and medicine, vol. 111, p. 103 345, 2019.
[20] Z. N. K. Swati et al., “Content-based brain tumor retrieval for mr images using transfer learning,” IEEE Access, vol. 7, pp. 17 809–17 822, 2019.
[21] E.-S. A. El-Dahshan, T. Hosny, and A.-B. M. Salem, “Hybrid intelligent techniques for mri brain images classification,” Digital signal processing, vol. 20, no. 2, pp. 433–441, 2010.
[22] A. Gumaei, M. M. Hassan, M. R. Hassan, A. Alelaiwi, and G. Fortino, “A hybrid feature extraction method with regularized extreme learning machine for brain tumor classification,” IEEE Access, vol. 7, pp. 36 266–36 273, 2019.
[23] A. K. Anaraki, M. Ayati, and F. Kazemi, “Magnetic resonance imaging-based brain tumor grades classification and grading via convolutional neural networks and genetic algorithms,” biocybernetics and biomedical engineering, vol. 39, no. 1, pp. 63–74, 2019.
[24] J. Cheng, Brain tumor dataset. figshare. dataset, 2018.
[25] G. Huang, Z. Liu, L. Van Der Maaten, and K. Q. Weinberger, “Densely connected convolutional networks,” in Proceedings of the IEEE conference on computer vision and pattern recognition, 2017, pp. 4700–4708.
[26] A. Jaiswal, N. Gianchandani, D. Singh, V. Kumar, and M. Kaur, “Classification of the covid-19 infected patients using densenet201 based deep transfer learning,” Journal of Biomolecular Structure and Dynamics, vol. 39, no. 15, pp. 5682–5689, 2021, PMID: 32619398. DOI: 10.1080/07391102. 2020 . 1788642. eprint: https : / / doi . org / 10 . 1080 / 07391102 . 2020 . 1788642. [Online]. Available: https://doi.org/10.1080/07391102.2020.1788642.
[27] M. Yaqub et al., “State-of-the-art cnn optimizer for brain tumor segmentation in magnetic resonance images,” Brain Sciences, vol. 10, no. 7, 2020, ISSN: 2076-3425. DOI: 10 . 3390 / brainsci10070427. [Online]. Available: https://www.mdpi.com/2076- 3425/10/ 7/427.
[28] R. Mehrotra, M. Ansari, R. Agrawal, and R. Anand, “A transfer learning approach for ai-based classification of brain tumors,” Machine Learning with Applications, vol. 2, p. 100 003, 2020.
[29] M. D. Zeiler, Adadelta: An adaptive learning rate method, 2012. arXiv: 1212.5701 [cs.LG].
[30] D. P. Kingma and J. Ba, Adam: A method for stochastic optimization, 2017. arXiv: 1412 . 6980 [cs.LG].