Journal of Cybersecurity and Information Management JCIM 2690-6775 2769-7851 10.54216/JCIM https://www.americaspg.com/journals/show/791 2019 2019 Faculty of Computers and Informatics, Zagazig University, Zagazig, Sharqiyah, 44519, Egypt Mohamed Abdel Abdel-Basset Faculty of Computers and Information, Mansoura University, Mansoura, 35516, Egypt Mohamed Elhoseny In the current epidemic situations, people are facing several mental disorders related to Depression, Anxiety, and Stress (DAS). Numerous scales are developed for computing the levels for DAS, and DAS-21 is one among them. At the same time, machine learning (ML) models are applied widely to resolve the classification problem efficiently, and feature selection (FS) approaches can be designed to improve the classifier results. In this aspect, this paper develops an intelligent feature selection with ML-based risk management (IFSML-RM) for DAS prediction. The IFSML-RM technique follows a two-stage process: quantum elephant herd optimization-based FS (QEHO-FS) and decision tree (DT) based classification. The QEHO algorithm utilizes the input data to select a valuable subset of features at the primary level. Then, the chosen features are fed into the DT classifier to determine the existence or non-existence of DAS. A detailed experimentation process is carried out on the benchmark dataset, and the experimental results showcased the betterment of the IFSML-RM technique in terms of different performance measures.  2021 2021 08 16 10.54216/JCIM.080101 https://www.americaspg.com/articleinfo/2/show/791