Fusion: Practice and Applications FPA 2692-4048 2770-0070 10.54216/FPA https://www.americaspg.com/journals/show/3222 2018 2018 Industrial Engineering Department, Penn State University, University park, State college, USA Thamer Thamer E-Commerce Department, Saudi Electronic University , Kingdom of Saudi Arabia Thamer Alhussain The pharmaceutical industry encounters numerous challenges in the management of medications and ensuring their authenticity, as well as safeguarding sensitive information within the supply chain. Maintaining the integrity of drug manufacturing processes, transaction records, and patient data from unauthorized access or tampering is crucial. Any breach in security could undermine trust throughout the entire supply chain.  To mitigate these concerns, a multi-layered approach is employed. Initially, data encryption using QR codes with Attribute-Based Encryption provides a foundation for securing information. This is followed by an innovative strategy that combines Red Panda Optimization (RPO) Algorithm and Group Teaching Optimization algorithms (GTOA) to optimize encryption key selection. Finally, Multi-Party Computation (MPC) protocols along with Shamir's Secret Sharing enhances overall security measures. These procedures ensure that only authorized individuals have access to critical information essential for identifying counterfeit products and maintain confidentiality through Secure MPC verification without compromising sensitive details. 2025 2025 62 78 10.54216/FPA.170206 https://www.americaspg.com/articleinfo/3/show/3222