Journal of Cybersecurity and Information Management JCIM 2690-6775 2769-7851 10.54216/JCIM https://www.americaspg.com/journals/show/2963 2019 2019 Research scholar, Department of Electronics Communication B. B. Associate professor, Department of Biomedical Engineering, Faculty of Engineering, Karpagam Academy of Higher Education, Coimbatore A. Mohanarathinam Leukemia, a cancer that attacks human white blood cells, is one of the deadliest illnesses.   Detecting affected cells in microscopic images becomes tedious because feature variants are not predicted correctly by a hematologist. Therefore image handling techniques failed to select the importance of the features scaling counts, entities, and precise size and shape of cells presented in the microscopic image. To resolve this problem, Deep Spectral Convolution Neural Network (DSCNN) based on Leukemia cancer detection using Invariant Entity Scalar Feature Selection (IESFS) is proposed to identify the risk factor of cancer for early diagnosis. Initially, preprocessing is carried out using cascade Gabor filters. Based on Structural Cascade Segmentation (SCS), the white blood cell regions are categorized into affected and non-affected margins and verify the edges using canny edge mapping. This estimates the scaling cell size, counts, entities and angular cell projection of weights from each segmented feature region. Then find the entity relation of cell projection equivalence using Color Intensive Histogram Equalization (CIHE). After segmenting the angular vector, projection scaling is applied to correlate the entity's object scaling comparator. Then scaling features were selected using Invariant Entity Scalar Feature Selection (IESFS) by averaging the mean depth values of feature weight and trained with a deep convolution neural network for predicting max equivalence entity weights for finding the affected cells and counts in microscopic images. This improves the prediction of cancer cell accuracy as well high performance in sensitivity 92.7 %, specificity 92.3 %, and f-measure 93.6 % with redundant time complexity.   2024 2024 33 52 10.54216/JCIM.140203 https://www.americaspg.com/articleinfo/2/show/2963