Journal of Cybersecurity and Information Management JCIM 2690-6775 2769-7851 10.54216/JCIM https://www.americaspg.com/journals/show/2900 2019 2019 College of Sciences for Women, University of Babylon, Hilla, Babel, Iraq Anfal Anfal College of Sciences for Women, University of Babylon, Hilla, Babel, Iraq Sahar Adil Kadhum The health information data includes reports on the patient’s condition, including addresses, names, tests, treatments, diagnoses, and medical history. It is sensitive information for patients, and all means of protection must be provided to prevent third parties from manipulation or fraudulent use. It has been discovered that DNA is now a reliable and efficient biological media for securing data. Data encryption is made possible by DNA's bimolecular computing powers. In this paper proposed a new strategy of safeguard the transfer of sensitive data over an unsecured network using cryptography with non-liner function, and DNA lossless compression to enhance security. The work gains best results in compression processes, as percentages range 75%. for character compression, the different rate ranges between 91% to 94%, and the compression rate ranges from 35% to 37%. the retrieving data with an accuracy rate up to 100% without any data loss, as well as excellent percentages within the Compression Ratio, Compression Factor, Error Rate, Accuracy measures. 2024 2024 197 206 10.54216/JCIM.140113 https://www.americaspg.com/articleinfo/2/show/2900