International Journal of Wireless and Ad Hoc Communication IJWAC 2692-4056 10.54216/IJWAC https://www.americaspg.com/journals/show/2778 2019 2019 Information Systems Department, Faculty of computers and Informatics, Zagazig University, Zagazig, Sharqiyah, 44519, Egypt Mahmoud Mahmoud Information Systems Department, Faculty of computers and Informatics, Zagazig University, Zagazig, Sharqiyah, 44519, Egypt Heba R. .. Information Systems Department, Faculty of computers and Informatics, Zagazig University, Zagazig, Sharqiyah, 44519, Egypt Ahmed A. Metwaly Information Systems Department, Faculty of computers and Informatics, Zagazig University, Zagazig, Sharqiyah, 44519, Egypt Mahmoud M. Ismail Healthcare 4.0, which is the integration of digital technologies in healthcare, promises to bring about revolutionary advancements but also introduces significant cybersecurity challenges. This research seeks to address the growing concerns by investigating security threats in healthcare 4.0 systems. The study uses a multifaceted methodology that includes a comprehensive literature review and empirical analysis using advanced algorithms such as Random Forest. Using visualization techniques, data distribution analysis, and intrusion detection experiments, the research identifies common vulnerabilities and patterns in healthcare 4.0 environments. The findings highlight the need for proactive measures and strong policies to protect patient data integrity, safeguard medical infrastructure, and ensure continuous provision of health care services. This study calls for a holistic approach to cyber security with an emphasis on collaborative efforts toward strengthening Healthcare 4.0 systems against emerging threats. 2024 2024 40 45 10.54216/IJWAC.080204 https://www.americaspg.com/articleinfo/20/show/2778