International Journal of Advances in Applied Computational Intelligence IJAACI 2833-5600 10.54216/IJAACI https://www.americaspg.com/journals/show/2001 2022 2022 Information System Department; October 6 University; Cairo, Egypt Alber S. Aziz Information System Department; October 6 University; Cairo, Egypt Haitham Rizk Fadlallah Hepatitis C Virus (HCV) is a worldwide epidemic. The World Health Organization estimates that annually between 3 and 4 million instances of HCV are recorded. People with HCV would benefit from knowing their illness stage earlier thanks to accurate and timely prognoses. Different noninvasive blood biochemical indicators and patient clinical data have been utilized to determine the disease phase. As a substitute for the invasive and sometimes harmful liver biopsy, machine learning approaches have shown useful in diagnosing each phase of this chronic liver disease. To accurately estimate HCV using sparse weather information, this work offers two machine learning (ML) methods: The Support Vector Machine (SVM) and a simple tree-based ensemble approach called Extreme Gradient Boosting (XGBoost). The two models are applied to real-world data on HCV. The dataset contains 13 variables and 615 cases. The results showed the SVM achieved more accuracy than the XGBoost. The SVM gets 93.5% accuracy and XGBoost gets 90.23% accuracy.  2023 2023 18 28 10.54216/IJAACI.030202 https://www.americaspg.com/articleinfo/31/show/2001