International Journal of Neutrosophic Science IJNS 2690-6805 2692-6148 10.54216/IJNS https://www.americaspg.com/journals/show/1021 2020 2020 Department of Computer Science, Al-Baha University, Al-Baha City, Kingdom of Saudi Arabia Mohammed I. Alghamdi Lung cancer is the abnormal development of cells in the lung causes serious risk to the health since lung has an interconnected system of blood vessel and lymphatic channel exposed to metastasis. The survival rate of lung cancer depends greatly on the earlier diagnosis and staging of the lung cancer. Computed Tomography (CT) image is commonly employed for lung cancer diagnosis since they offer data regarding distinct portions of the lung. The exactness of finding tumor location, volume and shape acting a major role in positive treatment and diagnosis of tumor. This article designs a novel neutrosophic set with adaptive neuro-fuzzy inference system for liver tumor segmentation and classification (NSANFIS-LTSC) model. The presented NSANFIS-LTSC model aims to identify and classify the presence of liver tumor from medical images. The presented NSANFIS-LTSC model primarily undergoes pre-processing to eradicate the noise. Followed by, the neutrosophic set (NS) based segmentation is applied to identify the affected tumor regions in the CT images. Besides, DenseNet-169 model is utilized to create feature vectors and dragonfly algorithm (DFA) is applied to tune the hyper parameters of the DenseNet-169 model. Finally, ANFIS classifier is exploited for the occurrence and classification of liver tumor. The simulation analysis of the NSANFIS-LTSC model is experimented using benchmark dataset and the results are investigated under several aspects. The simulation outcome reported the betterment of the NSANFIS-LTSC model over the recent methodologies.  2022 2022 174 185 10.54216/IJNS.180202 https://www.americaspg.com/articleinfo/21/show/1021