aspg-20-779-1791307524 20261006172524 American Scientific Publishing Group admin@americaspg.com American Scientific Publishing Group International Journal of Wireless and Ad Hoc Communication IJWAC 2692-4056 2021 2 2 Muhammad Edmerdash, Waleed khedr, Ehab Rushdy Department of Information Technology, Faculty of Computers and Informatics, Zagazig University, Zagazig, Egypt Cloud computing has brought a new paradigm shift to the technology industry and has become increasingly popular. Cloud communication is an emerging technology that can be combined with traditional healthcare management used to provide better healthcare services. Today, the adoption rate of cloud computing by small and medium enterprises (SMEs) is much higher than that of large companies. This triggered a debate about whether this cloud computing technology will penetrate the entire IT industry. Small and midsize enterprises are using cloud computing to deploy general IT infrastructure and software systems at low-cost, while large enterprises rely on their own infrastructure to ensure data security, privacy, and flexibility. One of the most demanded healthcare services that needs the cloud privileges is Drug-Drug Interaction – DDI. In this article, we have investigated different traditional systems compared to cloud-based systems, and as a privilege of providing system solutions to the public, what features the cloud brings to improve health management software. 2021 49 58 779 https://creativecommons.org/licenses/by/4.0/ 10.54216/IJWAC.020201 https://americaspg.com/journal/20/article/779 https://americaspg.com/storage/4281.pdf