aspg-41-4415-1792222808 20261017074008 American Scientific Publishing Group admin@americaspg.com American Scientific Publishing Group Metaheuristic Optimization Review MOR 3066-280X 2026 6 2 Ika Agustin Department of Mathematics, University of Jember, Jember, East Java, Indonesia Dwi Retnowardani Universitas PGRI Argopuro Jember, Indonesia Neurodevelopmental disorders are a broad category that estimates fifteen million people and include autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disabilities that, if not found at an early age, present substantial lifelong challenges. Modern technologies in artificial intelligence with generative models mean new possibilities in early diagnostics and prevention. This review aims to review the biomarker potentials of generative models, including GANs, VAEs, and diffusion models, in the early diagnosis of neurodevelopmental disabilities. Having synthesized what is currently known about these models, we explore how the models improve diagnostic precision, minimize the use of invasive procedures, and manage data deficiency. The significant applications discussed involve generative models in analyzing neuroimaging data, modeling speech and behavior, and synthesizing new datasets that are valuable in handling privacy issues and biased datasets. In addition, this paper discusses some of the limitations associated with generative model deployment in clinical practice; these include interpretability, model stability, and the fact that the models rely on extensive and diverse datasets. Finally, we bridge the gap by looking into the future and discussing what future research could bring and ethical concerns regarding generative models and their potential to revolutionize handling cases of early neurodevelopmental disorders and enable early, more effective interventional approaches. 2026 19 24 4415 https://creativecommons.org/licenses/by/4.0/ 10.54216/MOR.060203 https://americaspg.com/journal/41/article/4415 https://americaspg.com/storage/articles/manuscripts/01KVET8YNFXZJPX9F88HQYN0ZM.pdf