aspg-18-2684-1792025807 20261015005647 American Scientific Publishing Group admin@americaspg.com American Scientific Publishing Group Journal of Intelligent Systems and Internet of Things JISIoT 2769-786X 2690-6791 2024 12 2 Vinit P. Kharkar Assistant Professor, Department of Electronics & Telecommunication Engineering, Prof Ram Meghe College of Engineering and Management, Badnera-Amravati, MH, India. Ajay P. Thakare Professor, Department of Electronics & Telecommunication Engineering, Sipna College of Engineering and Technology, Amravati, MH, India Anemia, generally termed as deficiency of hemoglobin or red blood cells in the blood is significant global health concern for the population in underdeveloped as well as in developing nations specially, for children and young women in rural areas. This paper proposes a quantitative approach for anemia detection by regression analysis technique which predicts hemoglobin level in the blood. To achieve this, the image dataset of microscopic blood sample is collected from 70 individuals. The data collection requires proper procedure as it plays vital part in system implementation. The statistical feature utilizing mean pixel intensity values from the red, green, and blue color planes of the images are given as input to the regression model. For the proposed system, we have employed multiple regression analysis model using machine learning approach with both three and four regression coefficients to establish relation between features obtained from blood samples and the hemoglobin level in the blood to achieve the specified task of anemia detection in an individual. Performance analysis show promising results for the proposed system with co-efficient of determination (R2) and root mean square error (RMSE) found out be 0.923 and 1.682 respectively. Overall, this paper presents valuable system for anemia detection based on hemoglobin estimation which can be implemented in areas with limited medical resources and gives another supportive technological solution for current healthcare problems. 2024 34 43 2684 https://creativecommons.org/licenses/by/4.0/ 10.54216/JISIoT.120203 https://americaspg.com/journal/18/article/2684 https://americaspg.com/storage/11713494714.pdf